NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Coadministration may result in a significant decrease in renal function.
The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Coadministration of baricitinib with strong organic anion transporter 3 (OAT3) inhibitors is not recommended. Mefenamic acid will increase the level or effect of baricitinib by decreasing elimination. Mefenamic acid and apixaban both increase anticoagulation. Each drug may increase the photosensitizing effect of the other. Mefenamic acid, aminolevulinic acid topical.Įither increases toxicity of the other by pharmacodynamic synergism. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Aminolevulinic acid oral, mefenamic acid.Įither increases toxicity of the other by pharmacodynamic synergism.
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